Among the latter, 7 hearts had mural thrombi.Ĭonclusion: Recent research has suggested the important initiating and driving factor for PPCM is the shift in angiogenic balance and development of anti-angiogenic environment. Histologically, 12 hearts (48%) had myocarditis, while 13 (52%) had histological features of dilated cardiomyopathy. The patients had varied clinical presentation associated with preeclampsia, puerperal sepsis and postpartum haemorrhage. In the remaining 20 patients (80%), the diagnosis was made on the assessment of cardiac pathological features. Among these, 5 (20%) patients were clinically diagnosed as PPCM or dilated cardiomyopathy, where an echocardiology showed an ejection fraction <45%, presented with dyspnoea and had associated pregnancy-related disorders like eclampsia and acute fatty liver. Results: Among the 425 autopsies performed, 25 patients (5.8%) were diagnosed as PPCM on clinico-pathological basis. Samples were taken from right and left ventricular myocardia and examined by routine and/or special staining techniques. The hearts were dissected by the inflow-outflow method. Analysed details were demographics, duration and type of symptoms, clinical diagnosis and investigations. Methods: We conducted a retrospective autopsy study of pathologically diagnosed cases of PPCM in maternal deaths in tertiary centre from 2012 to 2020. Aim is to identify the clinical presentation and pathological features of PPCM among the maternal deaths. Hospital, Indiaīackground & objectives: Peripartum cardiomyopathy (PPCM) is an idiopathic left ventricular systolic dysfunction leading to cardiac failure in last trimester of pregnancy or in the postpartum period. Myocardial pathology in pregnancy - an autopsy study
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